Nelesen, 38, died in January of a burst blood vessel. The 13-year veteran reporter also was known in the area as a bartender, and he worked security every year at Milwaukee Summerfest.
"I'm doing it to try to do something good for the community out of something tragic that happened in my family," said Nelesen's brother, Tim, who is organizing the event.
The run will begin and end at St. Brendan's Inn, 234 S. Washington St., in Green Bay.
Andy wasn't a runner, but he liked brats and beer, and the event will feature plenty of both, Tim Nelesen said. Live music and a silent auction also will be featured.
Klement's Sausage Co. is helping to sponsor the event, and The Famous Klement's Racing Sausages will participate in the run.
The event will raise money and awareness for www.YesIWillWisconsin .com, an organ donation program. Andy Nelesen was an organ donor.
Onsite registration on the day of the event begins at 2 p.m. at St. Brendan's, where the starting and finishing line are. The race begins at 3:30 and the course mostly covers the Fox River Trail.
A silent auction will feature items such as a getaway package to New Glarus, a grill-brats-and-charcoal package, and a golf outing at The Bull in Sheboygan.
Tate Rooper of Appleton and members of the University of Wisconsin Marching Band will provide music, and hamburgers, hot dogs, brats and beer will be for sale.
The entertainment will begin around 4:30 p.m. when the last of the runners and walkers are in. It continues to 9 p.m.