Photo: Athletes gathered in the Peace Gardens. British Transplant Games in Sheffield 2008.
The event, which aims to raise awareness of the value of organ donation and help increase numbers on the NHS Organ Donor Register, will take place from August 15 to 18, 2013.
The games, organised by charity Transplant Sport UK, seeks to showcase the benefits of transplantation - while giving people aged between two and 80 who have undergone transplants the chance to compete in a wide range of sporting activities.
Last time the event was held in the city it attracted about 2,000 competitors and visitors providing a £500,000 boost to the local economy.
Council leader Julie Dore said: “We are extremely excited about the British Transplant Games returning to Sheffield next year.
“It’s a fantastic event for the profile of the city, raising awareness of a vital public health issue - transplantation, and the critical need for more organ donors to register.