Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania.
WASHINGTON -- Overweight and obese patients who donate one of their kidneys for transplant may be at risk of diminished function in the remaining organ, researchers said here.
In a meta-analysis, glomerular filtration rate fell significantly within the first year after transplant in overweight and obese donors (P=0.02), Kalyani Murthy, MD, of Tufts University in Boston, and colleagues reported at the National Kidney Foundation meeting here.
"Our analysis showed there is a risk of kidney damage for those people who are just overweight and not obese," Murthy said in a statement. "Transplant centers need to be aware of this when counseling potential donors."
Given the shortage of available donor organs, transplant centers have considered allowing overweight and obese patients to be potential donors. Those with a body mass index [BMI] over 30 are warned of an increased risk of developing chronic comorbid conditions after donation, while those with a BMI over 35 are typically turned away.
Some evidence has shown, however, that in addition to the risk of developing comorbid conditions, donors in the 30 to 35 BMI range also can be at risk of poor outcomes in the remaining kidney.
Read more: http://www.medpagetoday.com/MeetingCoverage/NKF/32721
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