Stuart Vince, 36, and Phil Jackson, 45, ran from Portsmouth to Land's End before making the return journey by kayak, on foot and bike.
The pair started the 260-mile trip on 20 May from the Queen's Alexander Hospital, Portsmouth.
Mr Vince organised the challenge after saving a friend's life by donating one of his own kidneys last year.'Highs and lows'
Bad weather forced them to abandoned their planned return trip by sea from in Plymouth; instead the pair ran and cycled back.
The final leg into Portsmouth was completed in windy conditions shortly after 15:00 BST.
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