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Newswise — SAN DIEGO, CA – JUNE 20, 2012 – Morbidly obese patients with end-stage organ failure may improve their chances for successful organ transplantation after laparoscopic sleeve gastrectomy, according to a new study* presented here at the 29th Annual Meeting of the American Society for Metabolic & Bariatric Surgery (ASMBS).
Though the study included only 26 patients whose average age was 57, researchers from the University of California, San Francisco (UCSF) School of Medicine say it is the largest study to examine the impact of gastric sleeve surgery on pre-transplant patients. Six patients had end-stage kidney disease and 20 patients had severely compromised liver function. Patients had an average body mass index (BMI) of 48.3 (about 125 pounds overweight) and all were candidates for a kidney or liver transplant, or both.
After gastric sleeve surgery, patients lost 17 percent of their excess weight at one month, 26 percent at three months, 50 percent at 12 months, and 66 percent at 24 months. Within nine months of surgery, one patient’s kidney function stabilized and he was taken off the transplant list, one patient had a combined liver and kidney transplant, one patient had a kidney transplant and six patients had liver transplants. Sixteen patients are currently on the transplant list and have lost enough weight to qualify for transplantation at UCSF. There were six complications among the group and one patient died four years later, while waiting for a transplant.
“This study suggests sleeve gastrectomy may be performed safely in carefully selected morbidly obese patients with impending organ failure and the significant weight loss they achieve may make them more suitable candidates for transplantation,” said lead study author Matthew Yi-Chih Lin, MD, a bariatric surgeon at the UCSF School of Medicine.
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