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Monday, July 2, 2012

European collaboration to design a biomimetic bioartificial liver

Medical News

Medicyte, The Electrospinning Company and the Universities of Manchester and Pisa launch a European wide unique project with the aim to design a biomimetic bioartificial liver (Re-Liver). The company GABO:mi ensures professional project management.

Within the European Union, 6% of the population is suffering from chronic liver diseases. And although the liver is one of the best-studied organs in the human body, therapeutic approaches are often precluded.

The scientists experienced several limitations for possible applications. On the one hand, suitable donor livers for solid organ transplant are in short supply and on the other hand, in-vitro and ex-vivo technologies for recapitulating liver function still fall short of reliability, consistency, and predictability.

The aim of Re-Liver is to reconstitute a standardized and reproducible bioartificial liver organoid (BLO) using healthy human liver as an architectural and biomaterial template. According to the EMA criteria, the BLO is a cell-based medicinal product, a highly innovative and complex medicine.

In addition to the Advanced Therapy Medicinal Product (ATMP), new diagnostic tools and further products in cell-based applications will be developed and validated by the Re-Liver Consortium, made up of three industrial partners, all SMEs, focusing the commercialisation of market-leading products across Europe and further afield.

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