Donor-recipient weight and sex mismatch may contribute to kidney transplant failure

NEPHROLOGY NEWS

A new study indicates that the success of a kidney transplant may rely in part on a kidney donor’s weight and sex, factors that are not typically considered when choosing a recipient for a deceased donor kidney. The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology, suggest that changes may be needed to current immunology-based protocols that match donors and recipients.


Previous research has shown that there may be a higher risk of kidney transplant failure if a kidney donor is smaller than the recipient, perhaps due to increased strain on the relatively smaller transplanted kidney. Very few studies have investigated outcomes associated with donor and recipient weight mismatch, however. There is also a suggestion that sex mismatch between kidney donor and recipient may lead to worse outcomes post-transplant, but studies have generated conflicting results.

To investigate these issues, a team led by Amanda Miller, MD, and Karthik Tennankore, MD, from Dalhousie University and the Nova Scotia Health Authority in Canada, examined whether receiving a kidney transplant from a smaller donor of the opposite sex would impact a recipient’s transplant outcomes. Continue reading
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